Detection of circular RNA expression and related quantitative trait loci in the human dorsolateral prefrontal cortex.

ABSTRACT:

Background

Circular RNAs (circRNAs) are implicated in various biological processes. As a layer of the gene regulatory network, circRNA expression is also an intermediate phenotype bridging genetic variation and phenotypic changes. Thus, analyzing circRNA expression variation will shed light on molecular fundamentals of complex traits and diseases.

Results

We systematically characterize 10,559 high-quality circRNAs in 589 human dorsolateral prefrontal cortex samples. We identify biological and technical factors contributing to expression heterogeneity associated with the expression levels of many circRNAs, including the well-known circRNA CDR1as. Combining the expression levels of circRNAs with genetic cis-acting SNPs, we detect 196,255 circRNA quantitative trait loci (circQT

SUBMITTER: Liu Z 

PROVIDER: S-EPMC6528256 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature