Bovine serum albumin-templated nanoplatform for magnetic resonance imaging-guided chemodynamic therapy.

ABSTRACT:

Background

Nanotechnology in medicine has greatly expanded the therapeutic strategy that may be explored for cancer treatment by exploiting the specific tumor microenvironment such as mild acidity, high glutathione (GSH) concentration and overproduced hydrogen peroxide (H₂O₂). Among them, tumor microenvironment responsive chemodynamic therapy (CDT) utilized the Fenton or Fenton-like reaction to produce excess hydroxyl radical (·OH) for the destruction of tumor cells. However, the produced ·OH is easily depleted by the excess GSH in tumors, which would undoubtedly impair the CDT's efficiency. To overcome this obstacle and enhance the treatment efficiency, we design the nanoplatforms for magnetic resonance imaging (MRI)-guided CDT.

Results

In this study,

SUBMITTER: Tang W 

PROVIDER: S-EPMC6528315 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature