APOE genotype and sex affect microglial interactions with plaques in Alzheimer's disease mice.

ABSTRACT: Microglia affect Alzheimer's disease (AD) pathogenesis in opposing manners, by protecting against amyloid accumulation in early phases of the disease and promoting neuropathology in advanced stages. Recent research has identified specific microglial interactions with amyloid plaques that exert important protective functions including attenuation of early pathology. It is unknown how these protective microglial interactions with plaques are affected by apolipoprotein E (APOE) genotype and sex, two well-established AD risk factors that modulate microglial function. We investigated this question using quantitative confocal microscopy to compare microglial interactions with amyloid plaques in male and female EFAD mice across APOE3 and APOE4 genotypes at 6 months of age. We observed that microg

SUBMITTER: Stephen TL 

PROVIDER: S-EPMC6528326 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature