Placental extract suppresses differentiation of 3T3-L1 preadipocytes to mature adipocytes via accelerated activation of p38 MAPK during the early phase of adipogenesis.

ABSTRACT:

Background

Adipogenesis, the process of preadipocyte differentiation to mature adipocytes accompanied by accumulation of intracytoplasmic lipid droplets, is regulated by various genetic and environmental factors, and closely associated with the development of obesity. Numerous recent studies suggest that some bioactive peptides and proteins derived from animals, and chemical compounds isolated from plants may be useful for prevention and treatment of obesity and obesity-related chronic diseases. In the present study, we examined the broad spectrum of effects of placental extract, with a focus on the influence of placental extract on adipogenesis.

Method

We cultured 3T3-L1 cells, which are widely used as a model of white preadipocytes, under differentiation conditions in the

SUBMITTER: Ando Y 

PROVIDER: S-EPMC6528359 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature