Effect of canonical NF-κB signaling pathway on the differentiation of rat dental epithelial stem cells.

ABSTRACT:

Background

Nuclear factor-κB (NF-κB), an important transcription factor, participates in many physiological and pathological processes such as growth, differentiation, organogenesis, apoptosis, inflammation, and immune response, including tooth development. However, it is still unknown whether NF-κB participates in the regulation of dental epithelial stem cells (DESCs) in postnatal rat incisors. Here, we investigated the specific differentiation regulatory mechanisms of the canonical NF-κB signaling pathway in DESCs and provided the mechanism of cross-talk involved in DESC differentiation.

Methods

After adding the activator or inhibitor of the NF-κB signaling pathway, Western blot and quantitative real-time PCR were used to analyze the expressions of amelogenesis-related gen

SUBMITTER: Liang Y 

PROVIDER: S-EPMC6528379 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature