Association of Crohn's disease with Foxp3 gene polymorphisms and its colonic expression in Chinese patients.

ABSTRACT:

Background

Fork head/winged helix transcription factor (Foxp3) plays a pivotal role in regulatory T (Treg) cells. The present study aimed to assess the association of Crohn's disease (CD) with Foxp3 polymorphisms and its colonic expression in Chinese patients.

Methods

The Foxp3 polymorphisms, rs3761547, rs2232365, rs2294021, and rs3761548, were examined by SNaPshot in 268 CD patients and 490 controls. The colonic expression levels of Foxp3, IL-2, and IL-4 were detected in 31 CD patients and 31 controls using real-time quantitative polymerase chain reaction, immunohistochemistry, and enzyme-linked immunosorbent assay.

Results

Compared to male controls, the proportion of variant allele of rs3761547 was increased in male patients. The variant alleles of rs3761547, rs2232

SUBMITTER: Xia S 

PROVIDER: S-EPMC6528575 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature