Aortic Strain Correlates with Elastin Fragmentation in Fibrillin-1 Hypomorphic Mice.

ABSTRACT:

Background

High frequency ultrasound has facilitated in vivo measurements of murine ascending aortas, allowing aortic strains to be gleaned from two-dimensional images. Thoracic aortic aneurysms associated with mutations in fibrillin-1 (FBN1) display elastin fragmentation, which may impact aortic strain. In this study, we determined the relationship between elastin fragmentation and aortic circumferential strain in wild type and fibrillin-1 hypomorphic (FBN1 ^mgR/mgR) mice.

Methods and results

Luminal diameters of the ascending aorta from wild type and FBN1 hypomorphic (FBN1 ^mgR/mgR) mice were measured in systole and diastole. Expansion of the ascending aorta during systole in male and female wild type mice was 0.21±0.02 mm (16.3%) a

SUBMITTER: Chen JZ 

PROVIDER: S-EPMC6528667 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature