Computational Modeling of Developing Cartilage Using Experimentally Derived Geometries and Compressive Moduli.

ABSTRACT: During chondrogenesis, tissue organization changes dramatically. We previously showed that the compressive moduli of chondrocytes increase concomitantly with extracellular matrix (ECM) stiffness, suggesting cells were remodeling to adapt to the surrounding environment. Due to the difficulty in analyzing the mechanical response of cells in situ, we sought to create an in silico model that would enable us to investigate why cell and ECM stiffness increased in tandem. The goal of this study was to establish a methodology to segment, quantify, and generate mechanical models of developing cartilage to explore how variations in geometry and material properties affect strain distributions. Multicellular geometries from embryonic day E16.5 and postnatal day P3 murine cartilage were imaged in three

SUBMITTER: Lycke RJ 

PROVIDER: S-EPMC6528734 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature