Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer.

ABSTRACT: The strategy of using existing drugs originally developed for one disease to treat other indications has found success across medical fields. Such drug repurposing promises faster access of drugs to patients while reducing costs in the long and difficult process of drug development. However, the number of existing drugs and diseases, together with the heterogeneity of patients and diseases, notably including cancers, can make repurposing time consuming and inefficient. The key question we address is how to efficiently repurpose an existing drug to treat a given indication. As drug efficacy remains the main bottleneck for overall success, we discuss the need for machine-learning computational methods in combination with specific phenotypic studies along with mechanistic studies, chemical ge

SUBMITTER: Nowak-Sliwinska P 

PROVIDER: S-EPMC6528778 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature