Pulmonary function and respiratory health after successful treatment of drug-resistant tuberculosis.

ABSTRACT:

Background

Post-treatment morbidity among subjects with drug-resistant tuberculosis (DR-TB) is unclear.

Methods

This was a cross-sectional study of patients from Tbilisi, Georgia with cavitary DR-TB and an outcome of cure. Participants had a chest X-ray (CXR), St. George Respiratory Quality (SGRQ) survey, and pulmonary function tests (PFTs) performed. Correlations between SGRQ and PFT results and factors associated with pulmonary impairment were examined.

Results

Among 58 subjects (median age 31 years), 40% used tobacco, 59% had prior TB, and 47% underwent adjunctive surgical resection. The median follow-up time was 41 months. Follow-up CXR revealed fibrosis in 30 subjects (52%) and bronchiectasis in seven (12%). The median forced expiratory volume (FEV₁)/f

SUBMITTER: Vashakidze SA 

PROVIDER: S-EPMC6528816 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature