Doxorubicin conjugated carbon dots as a drug delivery system for human breast cancer therapy.

ABSTRACT:

Objectives

Carbon dots (CDs) are one of the most promising carbon-based materials in bioimaging and drug/gene delivery applications. In this study, we have attempted to study the drug carrying capacity of highly fluorescent CDs for delivery of doxorubicin (DOX) and investigate the therapeutic activity of the CDs-DOX drug delivery system.

Materials and methods

Carbon dots were synthesized by means of a hydrothermal approach with mixing citric acid and ethylenediamine. The properties of CDs were characterized in respects of spectral property, zeta potential, particle morphology and chemical composition. The drug loading efficiency (DLE) and release profile of CDs-DOX were determined by a fluorescence spectrophotometer. We investigated the cellular toxicity and pharmaceutical a

SUBMITTER: Kong T 

PROVIDER: S-EPMC6528846 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature