Finasteride accelerates prostate wound healing after thulium laser resection through DHT and AR signalling.

ABSTRACT:

Objectives

Urinary tract infection, urinary frequency, urgency, urodynia and haemorrhage are common post-operative complications of thulium laser resection of the prostate (TmLRP). Our study mainly focuses on the role of finasteride in prostate wound healing through AR signalling.

Materials and methods

TmLRP beagles were randomly distributed into different treatment groups. Serum and intra-prostatic testosterone and DHT level were determined. Histological analysis was conducted to study the re-epithelialization and inflammatory response of the prostatic urethra in each group. We investigated the role of androgen in proliferation and inflammatory response in prostate. In addition, the effects of TNF-α on prostate epithelium and stromal cells were also investigated.

Results

SUBMITTER: Zhao R 

PROVIDER: S-EPMC6528864 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature