Prognostic values of long noncoding RNA PVT1 in various carcinomas: An updated systematic review and meta-analysis.

ABSTRACT: Cancers have been a worldwide health problem with a high mortality rate, but ideal biomarkers are not available to effectively screen and diagnose patients. Currently, an increasing number of long noncoding RNAs have been reported to be abnormally expressed in human carcinomas and play a vital role in tumourigenesis. Plasmacytoma variant translocation 1 (PVT1) is upregulated in various carcinomas, and its overexpression is associated with poor survival in cancer patients. We conduct an updated meta-analysis to determine its potential in prognosis for tumours. In total, 14 studies comprising 2435 patients were enrolled according to Reporting Recommendations for Tumour Marker Prognostic Studies guidelines. High PVT1 expression indicated poor overall survival (hazard ratio [HR] = 1.98, 95% co

SUBMITTER: Xiao M 

PROVIDER: S-EPMC6528925 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature