Cinnamomum cassia exhibits antileishmanial activity against Leishmania donovani infection in vitro and in vivo.

ABSTRACT:

Background

There is a pressing need for drug discovery against visceral leishmaniasis, a life-threatening protozoal infection, as the available chemotherapy is antiquated and not bereft of side effects. Plants as alternate drug resources has rewarded mankind in the past and aimed in this direction, we investigated the antileishmanial potential of Cinnamomum cassia.

Methodology

Dichloromethane, ethanolic and aqueous fractions of C. cassia bark, prepared by sequential extraction, were appraised for their anti-promastigote activity along with apoptosis-inducing potential. The most potent, C. cassia dichloromethane fraction (CBD) was evaluated for anti-amastigote efficacy in infected macrophages and nitric oxide (NO) production studied. The in vivo antileishmanial efficacy was a

SUBMITTER: Afrin F 

PROVIDER: S-EPMC6529017 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature