Depression Promotes the Onset of Irritable Bowel Syndrome through Unique Dysbiosis in Rats.

ABSTRACT:

Background/aims

Although studies using conventional animal models have shown that specific stressors cause irritable bowel syndrome (IBS), it is unclear whether depression itself causes IBS. Our aim was to establish a rat model to determine if depression itself promotes the onset of IBS and to elucidate the role of gut microbiota in brain-gut axis pathogenesis during coincident depression and IBS.

Methods

Rat models of depression were induced using our shuttle box method of learned helplessness. Visceral hypersensitivity was evaluated by colorectal distension (CRD) to diagnose IBS. Gut microbiota compositions were analyzed using high-throughput sequencing. In the subanalysis of rats without depression-like symptoms, rats with posttraumatic stress disorder (PTSD) were also ex

SUBMITTER: Takajo T 

PROVIDER: S-EPMC6529174 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature