Blood-Derived DNA Methylation Signatures of Crohn's Disease and Severity of Intestinal Inflammation.

ABSTRACT:

Background & aims

Crohn's disease is a relapsing and remitting inflammatory disorder with a variable clinical course. Although most patients present with an inflammatory phenotype (B1), approximately 20% of patients rapidly progress to complicated disease, which includes stricturing (B2), within 5 years. We analyzed DNA methylation patterns in blood samples of pediatric patients with Crohn's disease at diagnosis and later time points to identify changes that associate with and might contribute to disease development and progression.

Methods

We obtained blood samples from 164 pediatric patients (1-17 years old) with Crohn's disease (B1 or B2) who participated in a North American study and were followed for 5 years. Participants without intestinal inflammation or symptoms serv

SUBMITTER: Somineni HK 

PROVIDER: S-EPMC6529254 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature