Alterations of elastin in female reproductive tissues arising from advancing parity.

ABSTRACT: Female reproductive tissues undergo significant alterations during pregnancy, which may compromise the structural integrity of extracellular matrix proteins. Here, we report on modifications of elastic fibers, which are primarily composed of elastin and believed to provide a scaffold to the reproductive tissues, due to parity and parturition. Elastic fibers from the upper vaginal wall of virgin Sprague Dawley rats were investigated and compared to rats having undergone one, three, or more than five pregnancies. Optical microscopy was used to study fiber level changes. Mass spectrometry, ¹³C and ²H NMR, was applied to study alterations of elastin from the uterine horns. Spectrophotometry was used to measure matrix metalloproteinases-2,9 and tissue inhibitor of metallop

SUBMITTER: Dhital B 

PROVIDER: S-EPMC6529287 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature