Local and Global Influences of Visual Spatial Selection and Locomotion in Mouse Primary Visual Cortex.

ABSTRACT: Sensory selection and movement locally and globally modulate neural responses in seemingly similar ways. For example, locomotion enhances visual responses in mouse primary visual cortex (V1), resembling the effects of spatial attention on primate visual cortical activity. However, interactions between these local and global mechanisms and the resulting effects on perceptual behavior remain largely unknown. Here, we describe a novel mouse visual spatial selection task in which animals either monitor one of two locations for a contrast change ("selective mice") or monitor both ("non-selective mice") and can run at will. Selective mice perform well only when their selected stimulus changes, giving rise to local electrophysiological changes in the corresponding hemisphere of V1 including decre

SUBMITTER: McBride EG 

PROVIDER: S-EPMC6529288 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature