Chronic ethanol consumption alters lamina propria leukocyte response to stimulation in a region-dependent manner.

ABSTRACT: Chronic heavy alcohol consumption, also referred to as chronic heavy drinking (CHD), results in intestinal injury characterized by increased permeability, dysbiosis, nutrient malabsorption, potentially higher susceptibility to infection, and increased risk of colorectal cancer. However, our understanding of the mechanisms by which CHD results in intestinal damage remains incomplete. Here, we investigated the impact of chronic drinking on transcriptional and functional responses of lamina propria leukocytes (LPLs) isolated from the 4 major gut sections. Although no significant differences were detected between LPLs isolated from the ethanol and control groups at resting state within each major gut section, our analysis uncovered key regional differences in composition and function of LPLs i

SUBMITTER: Barr T 

PROVIDER: S-EPMC6529332 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature