From invasion to latency: intracellular noise and cell motility as key controls of the competition between resource-limited cellular populations.

ABSTRACT: In this paper we analyse stochastic models of the competition between two resource-limited cell populations which differ in their response to nutrient availability: the resident population exhibits a switch-like response behaviour while the invading population exhibits a bistable response. We investigate how noise in the intracellular regulatory pathways and cell motility influence the fate of the incumbent and invading populations. We focus initially on a spatially homogeneous system and study in detail the role of intracellular noise. We show that in such well-mixed systems, two distinct regimes exist: In the low (intracellular) noise limit, the invader has the ability to invade the resident population, whereas in the high noise regime competition between the two populations is found to

SUBMITTER: Guerrero P 

PROVIDER: S-EPMC6529359 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature