Characterization of circulating T-, NK-, and NKT cell subsets in patients with colorectal cancer: the peripheral blood immune cell profile.

ABSTRACT:

Objective

As the development and progression of colorectal cancer (CRC) are known to be affected by the immune system, cell subsets such as T cells, natural killer (NK) cells, and natural killer T (NKT) cells are considered interesting targets for immunotherapy and clinical biomarker research. Until now, the role of systemic immune profiles in tumor progression remains unclear. In this study, we aimed to characterize the immunophenotype of circulating T cells, NK cells, and NKT-like cells in patients with CRC, and to subsequently correlate these immunophenotypes to clinical follow-up data.

Methods

Using multiparameter flow cytometry, the subset distribution and immunophenotype of T cells (CD3⁺CD56^-), CD56^dim NK cells (CD3^-CD56

SUBMITTER: Krijgsman D 

PROVIDER: S-EPMC6529387 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature