Endocytosis, intracellular fate, accumulation, and agglomeration of titanium dioxide (TiO₂) nanoparticles in the rainbow trout liver cell line RTL-W1.

ABSTRACT: There is increasing evidence that titanium dioxide (TiO₂) nanoparticles (NPs) present in water or diet can be taken up by fish and accumulate in internal organs including the liver. However, their further fate in the organ is unknown. This study provides new insights into the interaction, uptake mechanism, intracellular trafficking, and fate of TiO₂ NPs (Aeroxide® P25) in fish liver parenchymal cells (RTL-W1) in vitro using high-resolution transmission electron microscopy (TEM) and single particle inductively coupled plasma mass spectrometry (spICP-MS) as complementary analytical techniques. The results demonstrate that following their uptake via caveolae-mediated endocytosis, TiO₂ NPs were trafficked through different intracellular compartments including e

SUBMITTER: Lammel T 

PROVIDER: S-EPMC6529399 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature