Coordinated representational reinstatement in the human hippocampus and lateral temporal cortex during episodic memory retrieval.

ABSTRACT: Theoretical models of episodic memory have proposed that retrieval depends on interactions between the hippocampus and neocortex, where hippocampal reinstatement of item-context associations drives neocortical reinstatement of item information. Here, we simultaneously recorded intracranial EEG from hippocampus and lateral temporal cortex (LTC) of epilepsy patients who performed a virtual reality spatial navigation task. We extracted stimulus-specific representations of both item and item-context associations from the time-frequency patterns of activity in hippocampus and LTC. Our results revealed a double dissociation of representational reinstatement across time and space: an early reinstatement of item-context associations in hippocampus preceded a later reinstatement of item information

SUBMITTER: Pacheco Estefan D 

PROVIDER: S-EPMC6529470 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature