Runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation.

ABSTRACT: Osteoarthritis (OA) results from an imbalance of the dynamic equilibrium between the breakdown and repair of joint tissues. Previously, we reported that Runx1 enhanced chondrogenic differentiation through transcriptional induction of COL2A1, and suppressed hypertrophic differentiation. Here, we investigated the involvement of Runx1 in OA development as well as its potential underlying molecular mechanism. When we analysed OA development in Col2a1-Cre;Runx1^fl/fl and Runx1^fl/fl mice by surgically inducing joint instability, Cartilage degradation and osteophyte formation of Col2a1-Cre;Runx1^fl/fl joints was accelerated compared with joints in Runx1^fl/fl animals 8 weeks after surgery. To investigate chondrocyte regulation by Runx1, we analysed interac

SUBMITTER: Yano F 

PROVIDER: S-EPMC6529519 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature