The Rate of CD4 T Cell Entry into the Lungs during Mycobacterium tuberculosis Infection Is Determined by Partial and Opposing Effects of Multiple Chemokine Receptors.

ABSTRACT: The specific chemokine receptors utilized by Th1 cells to migrate into the lung during Mycobacterium tuberculosis infection are unknown. We previously showed in mice that CXCR3⁺ Th1 cells enter the lung parenchyma and suppress M. tuberculosis growth, while CX3CR1⁺ KLRG1⁺ Th1 cells accumulate in the lung vasculature and are nonprotective. Here we quantify the contributions of these chemokine receptors to the migration and entry rate of Th1 cells into M. tuberculosis-infected lungs using competitive adoptive transfer migration assays and mathematical modeling. We found that in 8.6 h half of M. tuberculosis-specific CD4 T cells migrate from the blood to the lung parenchyma. CXCR3 deficiency decreases the average rate of Th1 cell ent

SUBMITTER: Hoft SG 

PROVIDER: S-EPMC6529656 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature