Microbiome Profiles of Ligature-Induced Periodontitis in Nonhuman Primates across the Life Span.

ABSTRACT: This investigation compared the microbiomes colonizing teeth during the initiation, progression, and resolution of periodontitis in nonhuman primates (Macaca mulatta) at different ages. Subgingival plaque samples were collected at baseline; 0.5, 1, and 3 months following ligature-induced periodontitis; and following naturally occurring disease resolution at 5 months. Samples were analyzed using 16S amplicon sequencing to identify bacterial profiles across age groups: young (<3 years of age), adolescent (3 to 7 years), adult (12 to 15 years), and aged (17 to 23 years). α-Diversity of the microbiomes was greater in the adult/aged samples than in the young/adolescent samples. β-Diversity of the samples demonstrated clear age group differences, albeit individual variation in microbiomes

SUBMITTER: Kirakodu S 

PROVIDER: S-EPMC6529664 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature