Therapeutic effect of Cnidium officinale Makino extract on ovariectomized hind-limb ischemic mice.

ABSTRACT:

Background

Cnidium officinale Makino (COM) has been used traditionally to treat female sexual disorders, such as amenorrhea, hypomenorrhea and oligomenorrhea, by improving blood circulation.

Methods

The present study aimed to investigate the alleviating effect of COM extracts on surgical injury-induced ischemia in the hind-limb of mice. In this study, female C57BL/6 mice were ovariectomized, and the vessels of the hind-limb were excised after ligation by surgical silk (6-0). The mice were orally administered with COM (150 or 300 mg/kg/day) for 3 weeks, and the blood flow rate of hind-limbs was evaluated by using a laser Doppler system after hind-limb ischemic surgery in an in vivo study. Additionally, the migration and tube formation of human umbilical vein end

SUBMITTER: Yang H 

PROVIDER: S-EPMC6529788 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature