Genetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy.

ABSTRACT: Purpose: GATA4 and GATA6 are known to have potential roles in vascular regulation by affecting vascular smooth muscle cell differentiation and atrial natriuretic peptide levels. The aim of this retrospective study was to investigate the associations between GATA4 and GATA6 polymorphisms and bleeding complication risk at a therapeutic international normalized ratio (INR) in patients with mechanical heart valves. Patients and methods: Study patients were included from the Ewha-Severance Treatment (EAST) Group of Warfarin. It consisted of 229 patients who received warfarin therapy after undergoing mechanical heart valve replacement and maintained a stable INR (INR of 2.0-3.0 for at least three consecutive times). Twenty single-nucleotide polymorphisms including

SUBMITTER: Yee J 

PROVIDER: S-EPMC6529806 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature