Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study.

ABSTRACT:

Objectives

To investigate the role of body mass index (BMI), systolic blood pressure, and smoking behaviour in explaining the effect of education on the risk of cardiovascular disease outcomes.

Design

Mendelian randomisation study.

Setting

UK Biobank and international genome-wide association study data.

Participants

Predominantly participants of European ancestry.

Exposure

Educational attainment, BMI, systolic blood pressure, and smoking behaviour in observational analysis, and randomly allocated genetic variants to instrument these traits in mendelian randomisation.

Main outcomes measure

The risk of coronary heart disease, stroke, myocardial infarction, and cardiovascular disease (all subtypes; all measured in odds ratio), and the degree to which

SUBMITTER: Carter AR 

PROVIDER: S-EPMC6529852 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature