Sudden Cardiac Death (SCD) - risk stratification and prediction with molecular biomarkers.

ABSTRACT: Sudden cardiac death (SCD) is a sudden, unexpected death that is caused by the loss of heart function. While SCD affects many patients suffering from coronary artery diseases (CAD) and heart failure (HF), a considerable number of SCD events occur in asymptomatic individuals. Certain risk factors for SCD have been identified and incorporated in different clinical scores, however, risk stratification using such algorithms is only useful for health management rather than for early detection and prediction of future SCD events in high-risk individuals. In this review, we discuss different molecular biomarkers that are used for early detection of SCD. This includes genetic biomarkers, where the majority of them are genomic variants for genes that encode for ion channels. Meanwhile, protein biom

SUBMITTER: Osman J 

PROVIDER: S-EPMC6530025 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature