Reduced eIF3d accelerates HIV disease progression by attenuating CD8+ T cell function.

ABSTRACT: BACKGROUND:In human immunodeficiency virus (HIV) infection, 10-15% of individuals exhibit a rapid decline in CD4+ T cells and become rapid progressors (RPs). Overall, understanding the factors affecting rapid disease progression in early HIV infection (EHI) can aid in treatment initiation. Recent studies show that eIF3s, classic scaffold proteins during the translation initiation process, can directly promote or inhibit the translation of mRNA, therefore participating in the regulation of cell function. However, to our knowledge, it has not been addressed whether eIF3s are involved in the diverse prognosis of HIV infection. METHODS:Expression of eIF3s in primary cells from early or chronic HIV-infected patients was detected by real-time PCR. To investigate the potential mechanisms of eIF3d

SUBMITTER: Pan Y 

PROVIDER: S-EPMC6530059 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature