Neurologic toxicity associated with immune checkpoint inhibitors: a pharmacovigilance study.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICI) produce durable antitumor responses but provoke autoimmune toxicities, including uncommon but potentially devastating neurologic toxicities. The clinical features, including the spectrum, timing, and outcomes, of ICI-induced neurologic toxicities are not well characterized.

Methods

We performed disproportionality analysis using Vigibase, the World Health Organization pharmacovigilance database, comparing neurologic adverse event (AE) reporting in patients receiving ICIs vs. the full database. Neurologic AEs were classified by group queries using Medical Dictionary for Regulatory Activities, between database inception to September 28, 2018. Associations between ICIs and neurologic AEs were assessed using reporting odds ratios (ROR

SUBMITTER: Johnson DB 

PROVIDER: S-EPMC6530194 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature