Comparative efficacy and acceptability of antidepressants in the long-term treatment of major depression: protocol for a systematic review and networkmeta-analysis.

ABSTRACT: INTRODUCTION:Pharmacotherapy plays an important role in the treatment of major depression. At the initiation of antidepressant treatment, both improvement of symptoms in the short term and relapse prevention in the long term should be taken into account. However, there is insufficient evidence regarding the efficacy and the acceptability of continuation/maintenance treatments and the relative efficacy/acceptability of antidepressants. OBJECTIVE:We will conduct a pairwise meta-analysis and a network meta-analysis (NMA) to examine the relative efficacy, tolerability and acceptability of antidepressants in the long-term treatment of major depression. METHODS AND ANALYSIS:We will include double-blind randomised controlled trials comparing any of the following antidepressants, which we included

SUBMITTER: Shinohara K 

PROVIDER: S-EPMC6530313 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature