Contaminant and Environmental Influences on Thyroid Hormone Action in Amphibian Metamorphosis.

ABSTRACT: Aquatic and terrestrial environments are increasingly contaminated by anthropogenic sources that include pharmaceuticals, personal care products, and industrial and agricultural chemicals (i. e., pesticides). Many of these substances have the potential to disrupt endocrine function, yet their effect on thyroid hormone (TH) action has garnered relatively little attention. Anuran postembryonic metamorphosis is strictly dependent on TH and perturbation of this process can serve as a sensitive barometer for the detection and mechanistic elucidation of TH disrupting activities of chemical contaminants and their complex mixtures. The ecological threats posed by these contaminants are further exacerbated by changing environmental conditions such as temperature, photoperiod, pond drying, food rest

SUBMITTER: Thambirajah AA 

PROVIDER: S-EPMC6530347 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature