Kanuka honey versus aciclovir for the topical treatment of herpes simplex labialis: a randomised controlled trial.

ABSTRACT:

Objective

To compare New Zealand medical grade kanuka honey with topical aciclovir for the treatment of herpes simplex labialis.

Design

Prospective parallel randomised controlled open-label superiority trial.

Setting

76 community pharmacies across New Zealand between 10 September 2015 and 13 December 2017.

Participants

952 adults randomised within the first 72 hours of a herpes simplex labialis episode.

Interventions

Random assignment 1:1 to either 5% aciclovir cream or medical grade kanuka honey (90%)/glycerine (10%) cream, both applied five times daily.

Outcome measures

The primary outcome was time from randomisation to return to normal skin (stage 7). Secondary outcomes included time from randomisation to stage 4 (open wound), time from stage 4

SUBMITTER: Semprini A 

PROVIDER: S-EPMC6530412 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature