Factors associated with adverse drug reaction occurrence and prognosis, and their economic impacts in older inpatients in Taiwan: a nested case-control study.

ABSTRACT:

Objective

Older patients are likely to have higher disease complexity and more drug prescriptions of which are associated with a higher incidence of adverse drug reactions (ADR). This study aimed to investigate factors associated with ADR occurrence, prognosis and medical expenses in older inpatients.

Design

A nested case-control study.

Setting

A medical centre located in north Taiwan.

Participants

539 reported ADR cases from a patient cohort containing 108 548 older inpatients were collected from 2006 to 2012. There were 1854 non-ADR matched controls; a maximum of 1:5 matched by age, sex and principal diagnosis were collected.

Exposure

Polypharmacy, the number of drugs prescribed, comorbidities and the admission department were factors associated with A

SUBMITTER: Liao PJ 

PROVIDER: S-EPMC6530431 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature