Fetal programming and Wilms tumor.

ABSTRACT:

Background

The "fetal programming" hypothesis has been evaluated in many adult diseases including cancer, but not for Wilms tumor. Wilms tumor has been related to high birthweight, but little is known about other growth metrics such as a baby's birth length, ponderal index, or placenta size, which can shed additional light on growth patterns.

Methods

Cases of Wilms tumor (N = 217) were taken from the Danish Cancer Registry, and controls (N = 4340) were randomly selected from the Population Register and matched to cases by sex and age. Linkage to the Medical Births Registry provided information on gestational factors and fetal growth measurements, while linkage to the Patient Register provided information on maternal and child health conditions.

Results

Despite having

SUBMITTER: Heck JE 

PROVIDER: S-EPMC6530460 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature