Abnormal medial prefrontal cortex functional connectivity and its association with clinical symptoms in chronic low back pain.

ABSTRACT: Accumulating evidence has shown that complicated brain systems are involved in the development and maintenance of chronic low back pain (cLBP), but the association between brain functional changes and clinical outcomes remains unclear. Here, we used resting-state functional magnetic resonance imaging (fMRI) and multivariate pattern analysis to identify abnormal functional connectivity (FC) between the default mode, sensorimotor, salience, and central executive brain networks in cLBP and tested whether abnormal FCs are related to pain and comorbid symptoms. Fifty cLBP patients and 44 matched healthy controls (HCs) underwent an fMRI scan, from which brain networks were identified by independent component analysis. Multivariate pattern analysis, graph theory approaches, and correlation analys

SUBMITTER: Tu Y 

PROVIDER: S-EPMC6530583 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature