Detection of Shared Balancing Selection in the Absence of Trans-Species Polymorphism.

ABSTRACT: Trans-species polymorphism has been widely used as a key sign of long-term balancing selection across multiple species. However, such sites are often rare in the genome and could result from mutational processes or technical artifacts. Few methods are yet available to specifically detect footprints of trans-species balancing selection without using trans-species polymorphic sites. In this study, we develop summary- and model-based approaches that are each specifically tailored to uncover regions of long-term balancing selection shared by a set of species by using genomic patterns of intraspecific polymorphism and interspecific fixed differences. We demonstrate that our trans-species statistics have substantially higher power than single-species approaches to detect footprints of trans-spec

SUBMITTER: Cheng X 

PROVIDER: S-EPMC6530816 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature