Molecular detection of Leptospira spp. in rats as early spatial predictor for human disease in an endemic urban area.

ABSTRACT: BACKGROUND:Leptospirosis is considered a neglected zoonosis associated with infrastructure problems and low socioeconomic status, particularly slums. Since the disease is mainly transmitted in urban settings by rat urine, this risk factor may be important predictor tool for prompt control and effective prevention at the local level in urban endemic areas. Accordingly, the present study aimed to propose an early spatial predictor tool for human leptospirosis in urban settings, to test the methodology of molecular methods for assessing Leptospira spp. in trapped rats, and report associated environmental data. METHODOLOGY/PRINCIPAL FINDINGS:Official city records and previous study were used to select risk factors for human leptospirosis in an endemic neighborhood of Curitiba, Brazil. Neighbor

SUBMITTER: Pellizzaro M 

PROVIDER: S-EPMC6530851 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature