Predicting future major depression and persistent depressive symptoms: Development of a prognostic screener and PHQ-4 cutoffs in breast cancer patients.

ABSTRACT:

Objective

Create a brief, self-report screener for recently diagnosed breast cancer patients to identify patients at risk of future depression.

Methods

Breast cancer patients (N = 410) within 2 ± 1 months after diagnosis provided data on depression vulnerability. Depression outcomes were defined as a high depressive symptom trajectory or a major depressive episode during 16 months after diagnosis. Stochastic gradient boosting of regression trees identified 7 items highly predictive for the depression outcomes from a pool of 219 candidate depression vulnerability items. Three of the 7 items were from the Patient Health Questionnaire 4 (PHQ-4), a validated screener for current anxiety/depressive disorder that has not been tested to identify risk for future depression. Threshol

SUBMITTER: Weihs KL 

PROVIDER: S-EPMC6531034 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature