Boolean network modeling in systems pharmacology.

ABSTRACT: Quantitative systems pharmacology (QSP) is an emerging discipline that aims to discover how drugs modulate the dynamics of biological components in molecular and cellular networks and the impact of those perturbations on human pathophysiology. The integration of systems-based experimental and computational approaches is required to facilitate the advancement of this field. QSP models typically consist of a series of ordinary differential equations (ODE). However, this mathematical framework requires extensive knowledge of parameters pertaining to biological processes, which is often unavailable. An alternative framework that does not require knowledge of system-specific parameters, such as Boolean network modeling, could serve as an initial foundation prior to the development of an ODE-bas

SUBMITTER: Bloomingdale P 

PROVIDER: S-EPMC6531050 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature