Autoimmune encephalitis with anti-IgLON5 and anti-GABAB-receptor antibodies: A case report.

ABSTRACT:

Rationale

Anti-IgLON5 disease is a complex neurological illness which is characterized by progressive sleep and movement disorders and defined by specific autoantibodies to IgLON5. We here describe the first case of a patient with coexisting anti-IgLON5 as well as anti-γ-aminobutyric acid B (GABAB)-receptor antibodies and predominant clinical features of anti-IgLON5 disease.

Patient concerns

The patient initially presented with subacute symptoms of severe sleep disorder, gait stability, dysarthria, cognitive impairment, depressive episode and hallucinations.

Diagnoses

The patient was diagnosed with autoimmune encephalitis, based on clinical features and positive anti-IgLON5 antibodies in serum as well as in cerebrospinal fluid and anti-GABAB-receptor antibodies in ser

SUBMITTER: Chung HY 

PROVIDER: S-EPMC6531245 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature