Efficient Hyperpolarization of U-¹³ C-Glucose Using Narrow-Line UV-Generated Labile Free Radicals.

ABSTRACT: Free radicals generated by UV-light irradiation of a frozen solution containing a fraction of pyruvic acid (PA) have demonstrated their dissolution dynamic nuclear polarization (dDNP) potential, providing up to 30 % [1-¹³ C]PA liquid-state polarization. Moreover, their labile nature has proven to pave a way to nuclear polarization storage and transport. Herein, differently from the case of PA, the issue of providing dDNP UV-radical precursors (trimethylpyruvic acid and its methyl-deuterated form) not involved in any metabolic pathway was investigated. The ¹³ C dDNP performance was evaluated for hyperpolarization of [U-¹³ C₆ ,1,2,3,4,5,6,6-d₇ ]-d-glucose. The generated UV-radicals proved to be versatile and highly efficient polarizing a

SUBMITTER: Capozzi A 

PROVIDER: S-EPMC6531289 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature