Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8⁺ T Cells.

ABSTRACT: Regulated activation of the cytokine TGF-β by integrins α_vβ₆ and α_vβ₈ expressed on keratinocytes is required for residence of epidermal-resident memory T cells, but whether skin-derived signals also affect recirculating memory cells in the skin remains unclear. Here, we show that after resolution of skin vaccinia virus (VV) infection, antigen-specific circulating memory CD8⁺ T cells migrated into skin. In mice lacking α_vβ₆ and α_vβ₈ integrins (Itgb6^-/-Itgb8^fl/fl-K14-cre), the absence of epidermal-activated TGF-β resulted in a gradual loss of E- or P-selectin-binding central and peripheral memory populations, which were rescued when skin entry was inhibited. Skin recircula

SUBMITTER: Hirai T 

PROVIDER: S-EPMC6531326 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature