Mitochondria function associated genes contribute to Parkinson's Disease risk and later age at onset.

ABSTRACT: Mitochondrial dysfunction has been implicated in the etiology of monogenic Parkinson's disease (PD). Yet the role that mitochondrial processes play in the most common form of the disease; sporadic PD, is yet to be fully established. Here, we comprehensively assessed the role of mitochondrial function-associated genes in sporadic PD by leveraging improvements in the scale and analysis of PD GWAS data with recent advances in our understanding of the genetics of mitochondrial disease. We calculated a mitochondrial-specific polygenic risk score (PRS) and showed that cumulative small effect variants within both our primary and secondary gene lists are significantly associated with increased PD risk. We further reported that the PRS of the secondary mitochondrial gene list was significantly asso

SUBMITTER: Billingsley KJ 

PROVIDER: S-EPMC6531455 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature