Functioning of Mycobacterial Heat Shock Repressors Requires the Master Virulence Regulator PhoP.

ABSTRACT: A hallmark feature of Mycobacterium tuberculosis pathogenesis lies in the ability of the pathogen to survive within macrophages under a stressful environment. Thus, coordinated regulation of stress proteins is critically important for an effective adaptive response of M. tuberculosis, the failure of which results in elevated immune recognition of the tubercle bacilli with reduced survival during chronic infections. Here, we show that virulence regulator PhoP impacts the global regulation of heat shock proteins, which protect M. tuberculosis against stress generated by macrophages during infection. Our results identify that in addition to classical DNA-protein interactions, newly discovered protein-protein interactions control complex mechanisms of expression of heat sh

SUBMITTER: Sevalkar RR 

PROVIDER: S-EPMC6531620 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature