Refugia and anthelmintic resistance: Concepts and challenges.

ABSTRACT: Anthelmintic resistance is a threat to global food security. In order to alleviate the selection pressure for resistance and maintain drug efficacy, management strategies increasingly aim to preserve a proportion of the parasite population in 'refugia', unexposed to treatment. While persuasive in its logic, and widely advocated as best practice, evidence for the ability of refugia-based approaches to slow the development of drug resistance in parasitic helminths is currently limited. Moreover, the conditions needed for refugia to work, or how transferable those are between parasite-host systems, are not known. This review, born of an international workshop, seeks to deconstruct the concept of refugia and examine its assumptions and applicability in different situations. We conclude that fa

SUBMITTER: Hodgkinson JE 

PROVIDER: S-EPMC6531808 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature