Identification of functional lipid metabolism biomarkers of brown adipose tissue aging.

ABSTRACT:

Objective

Aging is accompanied by loss of brown adipocytes and a decline in their thermogenic potential, which may exacerbate the development of adiposity and other metabolic disorders. Presently, only limited evidence exists describing the molecular alterations leading to impaired brown adipogenesis with aging and the contribution of these processes to changes of systemic energy metabolism.

Methods

Samples of young and aged murine brown and white adipose tissue were used to compare age-related changes of brown adipogenic gene expression and thermogenesis-related lipid mobilization. To identify potential markers of brown adipose tissue aging, non-targeted proteomic and metabolomic as well as targeted lipid analyses were conducted on young and aged tissue samples. Subsequentl

SUBMITTER: Gohlke S 

PROVIDER: S-EPMC6531832 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature