Dietary calories and lipids synergistically shape adipose tissue cellularity during postnatal growth.

ABSTRACT:

Objective

The susceptibility to abdominal obesity and the metabolic syndrome is determined to a substantial extent during childhood and adolescence, when key adipose tissue characteristics are established. Although the general impact of postnatal nutrition is well known, it is not clear how specific dietary components drive adipose tissue growth and how this relates to the risk of metabolic dysfunction in adulthood.

Methods

Adipose tissue growth including cell proliferation was analyzed in juvenile mice upon dietary manipulation with in vivo nucleotide labeling. The proliferative response of progenitors to specific fatty acids was assayed in primary cultures. Long-term metabolic consequences were assessed through transient dietary manipulation post-weaning with a second obes

SUBMITTER: Meln I 

PROVIDER: S-EPMC6531874 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature